IV型胶原α3结合蛋白抗体
规格：1mg/1ml
英文名： COL4A3BP
别名： Alpha 3 type IV collagen binding protein; C43BP_HUMAN; Ceramide transfer protein; Ceramide transporter; CERT; Cert protein; CERTL; col4a3bp; Collagen type IV alpha 3 (Goodpasture antigen) binding prot
分子量： 71kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human COL4A3BP
交叉反应：Human, Mouse, Rat, Cow, Rabbit,
细胞定位：细胞浆
IV型胶原α3结合蛋白抗体产品介绍：background: COL4A3BP is a kinase that specifically phosphorylates the N terminal region of the non collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Two transcripts exist for this gene. Function: Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. Subunit: Interacts with COL4A3. Interacts with VAPA and VAPB.IV型胶原α3结合蛋白抗体 Interaction with VAPB is less efficient than with VAPA. Subcellular Location: Cytoplasm. Golgi apparatus. Endoplasmic reticulum. Tissue Specificity: Widely expressed. Post-translational modifications: Phosphorylation on Ser-132 decreases the affinity toward phosphatidylinositol 4-phosphate at Golgi membranes and reduces ceramide transfer activity. Inactivated by hyperphosphorylation of serine residues by CSNK1G2/CK1 that triggers dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Similarity:IV型胶原α3结合蛋白抗体 Contains 1 PH domain. Contains 1 START domain. Database links: UniProtKB/Swiss-Prot: Q9Y5P4.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. COL4A3BP蛋白目前，主要用于Goodpasture综合征等方面的研究。
IV型胶原α3结合蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 细胞周期蛋白 激酶和磷酸酶 结合蛋白 细胞骨架 脂蛋白 细胞外基质
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid