自水解酶结构域5蛋白抗体
规格：1mg/1ml
英文名： ABHD5
别名： 1-acylglycerol-3-phosphate O-acyltransferase ABHD5; ABHD5; ABHD5_HUMAN; Abhydrolase domain containing 5; Abhydrolase domain containing protein 5; Abhydrolase domain-containing protein 5; CDS; CGI 58;
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ADHD5
交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
细胞定位：细胞浆
自水解酶结构域5蛋白抗体产品介绍：background: Abhd5 belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation. Widely expressed in various tissues, including skin, lymphocytes, liver, skeletal muscle and brain. Function: Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Subunit: Interacts with ADRP, PLIN and PNPLA2 (By similarity). Subcellular Location: Cytoplasm. Lipid droplet. Tissue Specificity: Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons. DISEASE: Defects in ABHD5 are the cause of Chanarin-Dorfman syndrome (CDS) [MIM:275630]; 自水解酶结构域5蛋白抗体also called triglyceride storage disease with impaired long-chain fatty acid oxidation or neutral lipid storage disease with ichthyosis. CDS is an autosomal recessive inborn error of lipid metabolism with multisystemic accumulation of triglycerides although plasma concentrations are normal. Clinical characteristics are congenital generalized ichthyosis, vacuolated leukocytes, hepatomegaly, myopathy, cataracts, neurosensory hearing loss and developmental delay. The disorder presents at birth with generalized, fine, white scaling of the skin and a variable degree of erythema resembling自水解酶结构域5蛋白抗体 non-bullous congenital ichthyosiform erythroderma. Similarity: Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily. Gene ID: 51099 Database links: Entrez Gene: 51099 Human Entrez Gene: 67469 Mouse Entrez Gene: 497624 Pig Entrez Gene: 316122 Rat Entrez Gene: 100125355 Sheep Omim: 604780 Human SwissProt: Q8WTS1 Human SwissProt: Q9DBL9 Mouse SwissProt: Q5EE05 Pig SwissProt: Q6QA69 Rat Unigene: 19385 Human Unigene: 280254 Mouse Unigene: 12459 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
自水解酶结构域5蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 **学 信号转导 脂蛋白 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid