紧密连接蛋白8抗体
规格：1mg/1ml
英文名： Claudin 8
别名： CLDN8; Claudin8; CLD 8; CLD8; CLDN 8; Claudin 8; Claudin-8; CLD8_HUMAN; OTTHUMP00000101915.
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Claudin
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞膜
紧密连接蛋白8抗体产品介绍：background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.紧密连接蛋白8抗体[provided by RefSeq, May 2010] Function: Plays a major role in tight junction-specific obliteration of the intercellular space. Subcellular Location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in the epididymis, mainly in the caput segment. Similarity: Belongs to the claudin family. Gene ID: 9073 Database links: Entrez Gene: 9073 Human Entrez Gene: 紧密连接蛋白8抗体54420 Mouse Entrez Gene: 304124 Rat Omim: 611231 Human SwissProt: P56748 Human SwissProt: Q9Z260 Mouse Unigene: 162209 Human Unigene: 25836 Mouse Unigene: 79297 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
紧密连接蛋白8抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid