转移生长因子β3（TGFβ3）抗体
规格：1mg/1ml
英文名： TGF beta 3
别名： ARVD; TGF beta 3; TGF beta3; TGF-beta-3; TGFB 3; TGFB3; TGFB3_HUMAN; transforming growth factor beta 3; Transforming growth factor beta-3.
分子量： 12/47kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TGF beta
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, Guinea Pig, G
细胞定位：分泌型蛋白
转移生长因子β3（TGFβ3）抗体产品介绍：background: Transforming growth factor beta s (TGF beta s) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGF beta. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. TGF beta 3 mediates many intercellular interactions that occur during embryonic development, cell differentiation and epithelial homeostasis. TGF beta 3 overexpresses in extramammary Paget’s disease (EPD) and downregulates in Bowen’s disease, indicating that its expression is a useful indicator of tumor activity. TGF beta 3 levels strongly correlate with IGF-1 and osteocalcin levels in serum. Significant amounts of TGF beta 3 circulation appear to be representative of TGF beta 3 expression in bone and may in part 转移生长因子β3（TGFβ3）抗体be derived from bone. Glucocorticoids may block TGF beta production by modulating mRNA levels and c-Jun activity. Function: Involved in embryogenesis and cell differentiation. Subunit: Homodimer; disulfide-linked. Interacts with ASPN. Subcellular Location: Secreted. DISEASE: Defects in TGFB3 are a cause of familial arrhythmogenic right ventricular dysplasia type 1 (ARVD1) ; also known as arrhythmogenic right ventricular cardiomyopathy 1 (ARVC1). ARVD is an autosomal dominant disease characterized by partial degeneration of the转移生长因子β3（TGFβ3）抗体 myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Similarity: Belongs to the TGF-beta family. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
转移生长因子β3（TGFβ3）抗体研究领域：肿瘤 细胞生物 信号转导 干细胞 生长因子和** 转录调节因子 血管内皮细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid