HOMER2抗体
规格：1mg/1ml
英文名： HOMER2
别名： ACPD; CPD; Cupidin; HOME2_HUMAN; HOMER 2; HOMER 2A; HOMER 2B; Homer homolog 2 (Drosophila); Homer homolog 3; Homer neuronal immediate early gene 2; Homer protein homolog 2; Homer-2; Homer2; HOMER2A; H
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HOMER2
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit,
细胞定位：细胞浆 细胞膜 细胞外基质
HOMER2抗体产品介绍：background: This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011] Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and mayHOMER2抗体 play an important role in maintaining the plasticity at glutamatergic synapses. Subunit: Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization. Subcellular Location: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface. Similarity: Belongs to the Homer family. Contains 1 WH1 domain.HOMER2抗体 Gene ID: 9455 Database links: Entrez Gene: 510811 Cow Entrez Gene: 9455 Human Entrez Gene: 26557 Mouse Entrez Gene: 29547 Rat Omim: 604799 Human SwissProt: Q9NSB8 Human SwissProt: Q9QWW1 Mouse SwissProt: O88801 Rat Unigene: 578443 Human Unigene: 228 Mouse Unigene: 30014 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
HOMER2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 染色质和核信号 神经生物学 信号转导 细胞凋亡 G蛋白偶联受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid