钠/钾离子转运ATP酶α2抗体
规格：1mg/1ml
英文名： Atp1a2
别名： AT1A2_HUMAN ; Atp1a2 ; FHM2 ; KIAA0778 ; MHP2 ; Na(+)/K(+) ATPase alpha-2 subunit ; Na+/K+ ATPase alpha 2 subunit ; Sodium potassium ATPase ; Sodium pump subunit alpha 2 ; Sodium pump subunit alpha-2
分子量： 112kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Atp1a2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞膜
钠/钾离子转运ATP酶α2抗体产品介绍：background: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008] Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the 钠/钾离子转运ATP酶α2抗体electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. Subcellular Location: Membrane. Cell membrane. DISEASE: Defects in ATP1A2 are the cause of migraine familial hemiplegic type 2 (FHM2) [MIM:602481]. FHM2 is a rare, severe, autosomal dominant subtype of migraine characterized by aura and some hemiparesis. Defects in ATP1A2 are a cause of alternating hemiplegia of childhood (AHC) [MIM:104290]. AHC is typically distinguished from familial hemiplegic migraine by infantile onset of the symptoms and high prevalence of associated neurological deficits that become increasingly obvious with age. Similarity: Belongs to the cation transport ATPase (P-type)钠/钾离子转运ATP酶α2抗体 (TC 3.A.3) family. Type IIC subfamily. Gene ID: 477 Database links: Entrez Gene: 477 Human Entrez Gene: 98660 Mouse Entrez Gene: 24212 Rat Omim: 182340 Human SwissProt: P50993 Human SwissProt: Q6PIE5 Mouse SwissProt: P06686 Rat Unigene: 34114 Human Unigene: 207432 Mouse Unigene: 1042 Rat Unigene: 214222 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钠/钾离子转运ATP酶α2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid