铁反应元件结合蛋白2抗体
规格：1mg/1ml
英文名： IREB2
别名： IRP 2; IRP-2; IRP2; ACO3; FLJ23381; IRE BP2; IRE-BP 2; IREB 2; IREB2; IREB2_HUMAN; iron regulatory protein 2; iron responsive element binding protein 2; Iron-responsive element-binding protein 2; irp2
分子量： 105kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IREB2
交叉反应：Human, Mouse, Rat, Chicken, Dog, Rabbit, Caenorhabditis elegans
细胞定位：细胞浆
铁反应元件结合蛋白2抗体产品介绍：background: Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins: IRP-1 and -2 (iron regulatory protein-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE-BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide. Function: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR 铁反应元件结合蛋白2抗体of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. Subcellular Location: Cytoplasm. Post-translational modifications: Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen. 铁反应元件结合蛋白2抗体Ubiquitinated by a SCF complex containing FBXL5. Upon iron and oxygen depletion FBXL5 is degraded, preventing ubiquitination and allowing its RNA-binding activity. Similarity: Belongs to the aconitase/IPM isomerase family. Gene ID: 3658 Database links: Entrez Gene: 3658 Human Entrez Gene: 475134 Dog Entrez Gene: 64602 Mouse Entrez Gene: 100153993 Pig Entrez Gene: 64831 Rat Omim: 147582 Human SwissProt: P48200 Human SwissProt: Q811J3 Mouse SwissProt: B3VKQ2 Pig SwissProt: Q62751 Rat Unigene: 436031 Human Unigene: 208991 Mouse Unigene: 10132 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
铁反应元件结合蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid