垂体同源盒蛋白1抗体
规格：1mg/1ml
英文名： PITX-1
别名： BFT; CCF; Hindlimb expressed homeobox protein backfoot; Hindlimb-expressed homeobox protein backfoot; Homeobox protein PITX1; LBNBG; Paired like homeodomain 1; Paired like homeodomain transcription fa
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PITX-1
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Guinea Pig,
细胞定位：细胞核
垂体同源盒蛋白1抗体产品介绍：background: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008] Function: May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Subcellular Location: Nucleus. DISEASE: Defects in PITX1 are a cause of congenital clubfoot (CCF) [MIM:119800]; also known as talipes equinovarus (TEV). Clubfoot is a congenital limb deformity defined as fixation of the foot in cavus, adductus, varus, and equinus (i.e.垂体同源盒蛋白1抗体 inclined inwards, axially rotated outwards, and pointing downwards) with concomitant soft tissue abnormalities. Clubfoot may occur in isolation or as part of a syndrome. Clubfoot appears to be a multifactorial trait. Similarity: Belongs to the paired homeobox family. Bicoid subfamily. Contains 1 homeobox DNA-binding domain. Gene ID: 5307 Database links: Entrez Gene: 5307 Human Entrez Gene:垂体同源盒蛋白1抗体 374201 Chicken Entrez Gene: 18740 Mouse Entrez Gene: 113983 Rat Omim: 602149 Human SwissProt: P56673 Chicken SwissProt: P78337 Human SwissProt: P70314 Mouse SwissProt: Q99NA7 Rat Unigene: 84136 Human Unigene: 135195 Mouse Unigene: 74248 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
垂体同源盒蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：发育生物学 信号转导 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid