蛋白酪氨酸磷酸酶受体PTPRB抗体
规格：1mg/1ml
英文名： PTPRB
别名： HPTP BETA; HPTPB; Phosphacan receptor type B; Protein tyrosine phosphatase receptor type B; Protein-tyrosine phosphatase beta; PTPB; PTPRB; PTPRB_HUMAN; R PTP BETA; R-PTP-beta; Receptor-type tyrosine-
分子量： 222kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PTPRB
交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
细胞定位：细胞膜
蛋白酪氨酸磷酸酶受体PTPRB抗体产品介绍：Function: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and 蛋白酪氨酸磷酸酶受体PTPRB抗体determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. Subunit: Monomer. Interacts with TEK. Interacts via fibronectin type-III 17 domain with CDH5 (By similarity). Subcellular Location: Membrane. Similarity: Belongs to蛋白酪氨酸磷酸酶受体PTPRB抗体 the protein-tyrosine phosphatase family. Receptor class 3 subfamily. Contains 17 fibronectin type-III domains. Contains 1 tyrosine-protein phosphatase domain. Gene ID: 5787 Database links: Swiss-Prot: P23467 human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白酪氨酸磷酸酶受体PTPRB抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞膜受体 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid