蛋白激酶C相关激酶1抗体
规格：1mg/1ml
英文名： PKN
别名： DBK; DPKN; PAK 1; PRK 1; PROTEIN KINASE C RELATED KINASE 1; SERINE/THREONINE PROTEIN KINASE N; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA.
分子量： 120kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PKN
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核 细胞浆 细胞膜
蛋白激酶C相关激酶1抗体产品介绍：background: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] Function: Pkc-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. May play a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, 蛋白激酶C相关激酶1抗体cell adhesion and transcription activation signaling processes (By similarity). Plays a role in regulating Rho-mediated dorsal closure during embryogenesis. Subunit: Interacts (via N-terminus) with Rho1 (via REM repeats), Rac1 (via REM 1 repeat) and Rac2. Subcellular Location: Cytoplasmic. Post-translational modifications: Phosphorylated (By similarity). Autophosphorylated; autophosphorylation is stimulated by GTP-bound Rho/Rac GTPases. Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 AGC-kinase C-terminal蛋白激酶C相关激酶1抗体 domain. Contains 1 C2 domain. Contains 1 protein kinase domain. Contains 3 REM (Hr1) repeats. Database links: Entrez Gene: 5585 Human Entrez Gene: 320795 Mouse Entrez Gene: 29355 Rat SwissProt: Q16512 Human SwissProt: P70268 Mouse SwissProt: Q63433 Rat SwissProt: Q6P748 Rat Unigene: 466044 Human Unigene: 213000 Mouse Unigene: 49880 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白激酶C相关激酶1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid