转化生长因子β调节蛋白1抗体
规格：1mg/1ml
英文名： TBRG1
别名： NIAM; Nuclear interactor of ARF and Mdm2; Transforming growth factor beta regulator 1; TBRG1; TBRG-1; TBRG 1; Transforming growth factor beta regulator 1.
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TBRG1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核
转化生长因子β调节蛋白1抗体产品介绍：background: Acts as a growth inhibitor. Can activate TP53/p53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. There are two isoforms. Function: Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis.转化生长因子β调节蛋白1抗体 Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. Subunit: Interacts with CDKN2A and MDM2. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed at low levels in most tissues, with highest levels 转化生长因子β调节蛋白1抗体in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma. Post-translational modifications: Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation. Similarity: Belongs to the TBRG1 family. Contains 1 FYR C-terminal domain. Contains 1 FYR N-terminal domain. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转化生长因子β调节蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 染色质和核信号 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid