尿苷二磷酸葡萄糖醛酸转移酶2B4抗体
规格：1mg/1ml
英文名： UGT2B4
别名： HLUG25; Hyodeoxycholic acid; UDP glucuronosyltransferase 2 family polypeptide B4; UDP glucuronosyltransferase 2B4 precursor; UDP glucuronyltransferase family 2 beta 4; UDP glycosyltransferase 2 family
分子量： 58kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human UGT2B4
交叉反应：Human, Sheep,
细胞定位：
尿苷二磷酸葡萄糖醛酸转移酶2B4抗体产品介绍：background: The UDP-Glucuronosyltransferases (UGT) comprise a family of enzymes that detoxify and enhance the urinary excretion of a wide variety of xenobiotic and endogenous substrates by transferring glucuronic acid to sulfhydryl, hydroxyl, aromatic amino, or carboxylic acid groups. They have been subdivided into two families, UGT1 and UGT2, based on the evolutionary divergence of their genes. The enzymes of the UGT1A family play an important role in the metabolism of dietary constituents, phenols, and therapeutic drugs, and also the glucuronidation of bilirubin and iodothyronines. The enzymes of the UGT2B family are involved in the metabolism of bile acids, phenol derivatives, catecholestrogens and steroids. Although it is widely recognized that the liver is the major 尿苷二磷酸葡萄糖醛酸转移酶2B4抗体site of glucuronidation, it is now clear that UGT enzymes are also found in extra-hepatic tissues. Function: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic 尿苷二磷酸葡萄糖醛酸转移酶2B4抗体acid. Subcellular Location: Microsome membrane; Single-pass membrane protein (Potential). Endoplasmic reticulum membrane; Single-pass membrane protein (Potential). Similarity: Belongs to the UDP-glycosyltransferase family. Database links: UniProtKB/Swiss-Prot: P06133.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
尿苷二磷酸葡萄糖醛酸转移酶2B4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 生长因子和**
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid