突触细胞粘附分子1抗体
规格：1mg/1ml
英文名： Neuroligin 1
别名： NLG 1; KIAA1070; MGC45115; NLG1; Neuroligin-1; NLGN1; NLGN1_HUMAN.
分子量： 87kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Neurolig
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
细胞定位：细胞浆 细胞膜
突触细胞粘附分子1抗体产品介绍：background: Neuroligin 1 is a synaptic cell-adhesion molecule that is enriched in postsynaptic densities where it may recruit receptors, channels, and signal-transduction molecules to synaptic sites of cell adhesion. In addition, the neuroligin/beta-neurexin junction may be involved in the excitatory/inhibitory specification of CNS neuron synapses. A role for Neuroligin 1 is also suggested in autism. Function: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Subunit: Interacts with NRXN1, NRXN2 and NRXN3. Interacts with NLGN3. Interacts with AIP1 and PDZRN3. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with GOPC. Subcellular Location: Cell membrane; Single-pass type I membrane 突触细胞粘附分子1抗体protein. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Detected at dendritic spines. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1. Tissue Specificity: Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells. Similarity: Belongs to the type-B carboxylesterase/lipase family. Gene ID: 22871 Database links: Entrez Gene: 22871 Human Entrez Gene: 1突触细胞粘附分子1抗体92167 Mouse Entrez Gene: 116647 Rat Omim: 600568 Human SwissProt: Q8N2Q7 Human SwissProt: Q99K10 Mouse SwissProt: Q62765 Rat Unigene: 478289 Human Unigene: 316080 Mouse Unigene: 10173 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产突触细胞粘附分子1抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-300 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学 细胞粘附分子 细胞表面分子 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid