可溶性凝集素样氧化低密度脂蛋白受体1抗体
规格：1mg/1ml
英文名： sLOX 1
别名： Soluble Lectin-like oxidized low density lipoprotein receptor-1; sLOX-1; soluble form, C-type lectin domain family 8 member A; CLEC8A; hLOX 1; hLOX-1; Lectin like oxidized LDL receptor 1; Lectin like
分子量： 31kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human sLOX 1
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜 分泌型蛋白
可溶性凝集素样氧化低密度脂蛋白受体1抗体产品介绍：background: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. Function: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide 可溶性凝集素样氧化低密度脂蛋白受体1抗体(NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. Subcellular Location: Cell membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form also exists. Tissue Specificity: Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level. Post-translational modifications: The intrachain disulfide-bonds prevent N-glycosylation at some sites. N-glycosylated. DISEASE: Note=Independent association genetic studies have implicated 可溶性凝集素样氧化低密度脂蛋白受体1抗体OLR1 gene variants in myocardial infarction susceptibility. Similarity: Contains 1 C-type lectin domain. Gene ID: 4973 Database links: Entrez Gene: 4973 Human Entrez Gene: 108078 Mouse Entrez Gene: 140914 Rat Omim: 602601 Human SwissProt: P78380 Human SwissProt: Q9EQ09 Mouse SwissProt: O70156 Rat Unigene: 412484 Human Unigene: 293626 Mouse Unigene: 87449 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
可溶性凝集素样氧化低密度脂蛋白受体1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 **学 合成与降解
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid