磷脂酶C1样蛋白抗体
规格：1mg/1ml
英文名： PLDL1
别名： PLDL1; PLCE; Phospholipase C deleted in lung carcinoma; Phospholipase C epsilon; Phospholipase C like 1; Phospholipase C related but catalytically inactive protein; Phospholipase C related, but cataly
分子量： 123kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PLDL1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：
磷脂酶C1样蛋白抗体产品介绍：background: PLCL1 is involved an inositol phospholipid based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and sphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C. Function: Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as a inhibitor of PPP1C. Subunit: Interacts with PPP2CA By similarity. Interacts with Ins(1,4,5)P3, Ins(1,4,5,6)P4, GABARAP, GABA receptor beta subunits, GABA receptor gamma-2 subunits and PPP1C. May form a ternary complex with GABA receptor beta subunit and GABARAP. The formation 磷脂酶C1样蛋白抗体of a ternary complex with GABA receptor beta subunit and GABARAP could be the key step for facilitating the association of GABARAP with the GABA receptor gamma-2 subunit and to allow it to be transported at the right destination. Subcellular Location: Cytoplasmic Tissue Specificity: Expressed in a variety of fetal and ***** organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain. Post-translational modifications: Phosphorylated by the catalytic subunit 磷脂酶C1样蛋白抗体of PKA. Phosphorylation of Thr-93 resulted in dissociation of PPP1C from PRIP1 Similarity: Contains 1 C2 domain. Contains 1 PH domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain. Database links: Entrez Gene: 5334 Human Omim: 600597 Human SwissProt: Q15111 Human Unigene: 153322 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷脂酶C1样蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid