谷氨酰胺合成酶/谷氨酸氨连接酶抗体
规格：1mg/1ml
英文名： Glutamine synthetase
别名： GLNA; GLNS; GLUL; Gl Syn; glutamate-ammonia ligase; glutamine synthetase; GS; PIG 43; PIG 59; PIG43; PIG59; Proliferation inducing protein 43.
分子量： 42kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Gl Syn
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆 线粒体
谷氨酰胺合成酶/谷氨酸氨连接酶抗体产品介绍：background: Glutamine Synthetase catalyzes the conversion of ammonia and glutamate to glutamine. It is found in astrocytes as an octamer of identical 42 kDa subunits. The function of Glutamine Synthetase is the detoxification of brain ammonia. It also has an important role in the metabolic regulation of neurotransmitter glutamate. Because of the multiple functions and importance of Glutamine Synthetase in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of Glutamine Synthetase is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. The level of expression of Glutamine Synthetase is increased during ischemia in vivo or hypoxia in culture. Function: This enzyme has 2 functions: it catalyzes the production of glutamine and 谷氨酰胺合成酶/谷氨酸氨连接酶抗体4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts. Subcellular Location: Cytoplasm. Mitochondrion. DISEASE: Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid. Similarity: Belongs to the glutamine synthetase family. Database links: Entrez Gene: 2752 Human Entrez Gene: 281199 Cow Entrez Gene: 403443 Dog Entrez谷氨酰胺合成酶/谷氨酸氨连接酶抗体 Gene: 14645 Mouse Entrez Gene: 24957 Rat Omim: 138290 Human SwissProt: P15103 Cow SwissProt: Q8HZM5 Dog SwissProt: P15104 Human SwissProt: P15105 Mouse SwissProt: P09606 Rat Unigene: 518525 Human Unigene: 210745 Mouse Unigene: 2204 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
谷氨酰胺合成酶/谷氨酸氨连接酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学 信号转导 线粒体 Alzheimer's
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid