转化生长因子β活化激酶结合蛋白1抗体
规格：1mg/1ml
英文名： TAB1
别名： MAP3K7IP 1; MAP3K7IP1; Mitogen activated protein kinase kinase kinase 7 interacting protein 1; TAB 1; TAK1 binding protein 1; TGF beta activated kinase 1 binding protein 1; TGF-beta activated kinase 1
分子量： 55 kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAP3K7IP
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：
转化生长因子β活化激酶结合蛋白1抗体产品介绍：background: TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta and members of the Toll IL 1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N terminus acts as a dominant negative inhibitor of TGF beta, demonstrating how this protein can function as a mediator between TGF beta receptors and TAK1. Function: May be an important signaling intermediate between转化生长因子β活化激酶结合蛋白1抗体TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Subunit: Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Tissue Specificity: Ubiquitous. Post-translational modifications: Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP. Similarity: Contains 1 PP2C-like domain. Gene ID: 10454 Database links: Entrez Gene: 10454 Human Entrez Gene: 66513 Mouse Entrez Gene: 315139 转化生长因子β活化激酶结合蛋白1抗体Rat Omim: 602615 Human SwissProt: Q15750 Human SwissProt: Q8CF89 Mouse Unigene: 507681 Human Unigene: 288245 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转化生长因子β活化激酶结合蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导 转录调节因子 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid