GLP1类似蛋白Exendin4抗体
规格：1mg/1ml
英文名： Exendin 4
别名： Exendin 4; Exendin4; Exendin-4; EXE4_HELSU .
分子量： 4.3kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from Gila monster l
交叉反应：Gila monster lizard
细胞定位：
GLP1类似蛋白Exendin4抗体产品介绍：background: Exendin 4 is a 39 amino acid peptide found in venom from the Gila monster Helicoderma suspectum. It is a member of the glucagon secretin family of peptide hormones and neuropeptides. Exendin 4 is a potent agonist of the GLP1 receptor and hence a potent stimulator of insulin secretion. Function: Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibitsGLP1类似蛋白Exendin4抗体 gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle. Subcellular Location: Secreted. Tissue Specificity: Expressed by the venom gland. Similarity: Belongs to the glucagon family. Database links: UniProtKB/Swiss-Prot: P26349.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Exendin-4是从希拉毒蜥唾液中分离的一种多肽**,由39个氨基酸残基组成,与胰高血糖素样肽1(GLP-1)有53%的同源性。GLP1类似蛋白Exendin4抗体Exendin-4具有高度的组织特异性,仅在希拉毒蜥的唾液腺中表达, 具有促进葡萄糖依赖性的胰岛素分泌、促进β细胞增殖、减慢胃排空、抑制食物摄取和减轻体重等作用。 肠促胰岛素类似物（exendin-4，Ex-4）是从美洲一种毒蜥的唾液中分泌的胰升糖素样肽-1（glucagon-like peptide-1，GLP-1）类似物，它具有促进胰腺胰岛素的分泌、增加胰岛素敏感性及改善胰岛细胞功能的作用，且不被二肽基肽酶Ⅳ（DPP-Ⅳ）分解，血浆半衰期较长，因而在人类，对糖尿病**应用来说是稳定、长效的有**前景的**。 钝尾毒蜥 (Gila monster)
GLP1类似蛋白Exendin4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学 糖尿病
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid