形态发生紊乱关联激活因子1抗体
规格：1mg/1ml
英文名： DAAM1
别名： DAAM 1; DAAM-1; Dishevelled associated activator of morphogenesis 1; FLJ41657; KIAA0666; DAAM1_HUMAN.
分子量： 123kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DAAM1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
形态发生紊乱关联激活因子1抗体产品介绍：background: DAAM1 (Dishevelled associated activator of morphogenesis 1) is a diaphanous-related formin which binds to dishevelled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex assembly. It is an essential component of noncanonical Wnt signaling. DAAM1 also communicates with Rho GTPases, CIP4 and Src in the regulation of the signalling pathways that co-ordinate the dynamics of the actin filament system. DAAM1 may be a coordinator of endocytosis and cytoskeletal remodeling. Function: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein形态发生紊乱关联激活因子1抗体 to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Subunit: Homodimer. Interacts with CIP4, FNBP1 and FNBP1L. Interacts with the SH3 domains of Abl, BTK, endophilin, spectrin and SRC. Binds specifically to GTP-bound CDC42 and RHOA. Subcellular Location: Cytoplasm. Note=Perinuclear. Tissue Specificity: 形态发生紊乱关联激活因子1抗体Expressed in all tissues examined. Database links: Belongs to the formin homology family. Contains 1 DAD (diaphanous autoregulatory) domain. Contains 1 FH1 (formin homology 1) domain. Contains 1 FH2 (formin homology 2) domain. Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. DAAM1是蓬乱蛋白相关形态形成活化因子1或称形态发生紊乱形态发生紊乱关联激活因子1抗体关联激活因子1，为形成素蛋白家族的成员。Daam1是WNT/PCP通路的组成因子之一,参与细胞的内吞功能,可调节细胞骨架的形成与构建.
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid