磷酸化环磷酸腺苷反应元件调节蛋白抗体
规格：1mg/1ml
英文名： phospho-CREM (Ser271 +Ser 274)
别名： CREM (phospho S271 + S274); p-CREM (phospho S271 + S274); cAMP response element modulator; cAMP responsive element modulator; hCREM 2; hCREM2; ICER; Inducible cAMP early repressor; Inducible cAMP earl
分子量： 40kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Chicken, Pig, Horse,
细胞定位：细胞核
磷酸化环磷酸腺苷反应元件调节蛋白抗体产品介绍：background: CREM is a a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is derived from a multiexonic gene that encodes both activators and antagonists of cAMP-inducible transcription by differential splicing. Splice variants with antagonistic function lack 2 glutamine-rich domains and block cAMP-induced transcription, whereas an isoform that includes these glutamine-rich domains is a transcriptional activator. Function: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation. Subunit: Binds DNA as a dimer. 磷酸化环磷酸腺苷反应元件调节蛋白抗体Interacts with FHL5. Interacts with CDC34. Subcellular Location: Nucleus. Tissue Specificity: Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. Post-translational modifications: Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome. Stimulated by phosphorylation. Similarity: Belongs to the bZIP 磷酸化环磷酸腺苷反应元件调节蛋白抗体family. Contains 1 bZIP domain. Contains 1 KID (kinase-inducible) domain. Database links: Entrez Gene: 403887 Dog Entrez Gene: 1390 Human Entrez Gene: 12916 Mouse Entrez Gene: 25620 Rat Omim: 123812 Human SwissProt: P79145 Dog SwissProt: Q03060 Human SwissProt: P27699 Mouse SwissProt: Q03061 Rat Unigene: 200250 Human Unigene: 10251 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化环磷酸腺苷反应元件调节蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 转录调节因子 激酶和磷酸酶 结合蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid