自噬蛋白5/细胞凋亡的特异性蛋白抗体
规格：1mg/1ml
英文名： APG5L
别名： ATG5; APG 5; APG 5L; APG5; APG5 autophagy 5 like; APG5 like; APG5-like; APG5L; Apoptosis specific protein; Apoptosis-specific protein; ASP; ATG 5; ATG5; ATG5 autophagy related 5 homolog; Autophagy pro
分子量： 50kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human APG5L
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
自噬蛋白5/细胞凋亡的特异性蛋白抗体产品介绍：background: In yeast, autophagy is an essential process for survival during nutrient starvation and cell differentiation. The process of autophagy is characterized as a non-selective degradation of cytoplasmic proteins into membrane stuctures called autophagosomes, and it is dependent on several proteins, including the autophagy proteins APG5 and APG7. Yeast Apg7 and the human homolog, APG7, share similarities with the ubiquitin-activating enzyme E1 in Saccharomyces cerevisiae and are likewise responsible for enzymatically activating the autophagy conjugation system. Apg5 and the human homolog, APG5 (also designated apoptosis-specific protein or APS), function as substrates for the autophagy protein Apg12. These proteins are covalently bonded together to form Apg12/APG5 conjugates, which are required for the progression of autophagy. Function: Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity). May play an important role in the apoptotic process, possibly within the modified cytoskeleton. 自噬蛋白5/细胞凋亡的特异性蛋白抗体Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Subunit: The ATG5-ATG12 conjugate forms a complex with several units of ATG16. Interacts with TECPR1; the interaction is direct and does not take place when ATG16 is associated with the ATG5-ATG12 conjugate. Subcellular Location: Cytoplasm. Note=Colocalizes with nonmuscle actin. Tissue Specificity: Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. Post-translational modifications: Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation 自噬蛋白5/细胞凋亡的特异性蛋白抗体membrane. Similarity: Belongs to the ATG5 family. Database links: Entrez Gene: 9474 Human Entrez Gene: 11793 Mouse Entrez Gene: 365601 Rat Omim: 604261 Human SwissProt: Q9H1Y0 Human SwissProt: Q99J83 Mouse SwissProt: Q3MQ06 Rat Unigene: 486063 Human Unigene: 22264 Mouse Unigene: 98385 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
自噬蛋白5/细胞凋亡的特异性蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid