谷草转氨酶抗体
规格：1mg/1ml
英文名： Aspartate Aminotransferase
别名： AATC_HUMAN; Aspartate aminotransferase 1; Aspartate aminotransferase; Aspartate aminotransferase cytoplasmic; Aspartate aminotransferase cytosolic; cytoplasmic; ec 2.6.1.1; GIG 18; GIG18; Glutamate ox
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Aspartat
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
细胞定位：
谷草转氨酶抗体产品介绍：background: Aspartate Aminotransferase [Glutamate oxaloacetate transaminase] is a ubiquitous pyridoxal phosphate-dependent enzyme which exists in both mitochondrial and cytosolic forms. The enzyme plays an important role in amino acid metabolism and in the urea and tricarboxylic acid cycles. The 2 isoenzymes are homodimeric. In liver about 80% of the enzyme activity is mitochondrial in origin, whereas in serum the enzyme activity is largely cytosolic. Although the mitochondrial and soluble forms of GOT are coded by different chromosomes, the 2 show close homology in amino acid sequence and were presumably derived from a common ancestral gene. Function: Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter 谷草转氨酶抗体of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, 谷草转氨酶抗体regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. Subunit: Homodimer. Subcellular Location: Cytoplasm. Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Database links: UniProtKB/Swiss-Prot: P17174.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
谷草转氨酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid