肌萎缩侧索硬化症相关蛋白2（2号染色体）抗体
规格：1mg/1ml
英文名： ALS2CR2
别名： Amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 2; CALS 21; ILP interacting protein ILPIPA; ILPIP; ILPIPA; Likely ortholog of mouse polyploidy associated protein kinase; PAPK; P
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ALS2CR2
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核 细胞浆
肌萎缩侧索硬化症相关蛋白2（2号染色体）抗体产品介绍：background: Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2, is connected to transferase/kinase activity and ATP binding, it has recently been shown to interact with XIAP, a member of the IAP (Inhibitor of Apoptosis) protein family. Together, these two proteins synergistically activate the TAK1/JNK1 signal transduction pathway, which acts to protect against the interleukin-1 converting enzyme of Fas-induced apotosis. This protein was independently isolated and characterized as polyploidy-associated protein kinase (PAPK), a member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival, suggesting that its protective role may be a function of its kinase activity. Although two mRNA sequences have been isolated, 肌萎缩侧索硬化症相关蛋白2（2号染色体）抗体only the shorter isoform has been observed. Subunit: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Interacts with BIRC4/XIAP. These two proteins are likely to coexist in a肌萎缩侧索硬化症相关蛋白2（2号染色体）抗体 complex with TAK1, TRAF6, TAB1 and TAB2 Subcellular Location: Nucleus. Cytoplasm. Tissue Specificity: Highly expressed in heart, skeletal muscle, testis, liver and colon. Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 protein kinase domain. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肌萎缩侧索硬化症相关蛋白2（2号染色体）抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid