腺苷酸环化酶6抗体
规格：1mg/1ml
英文名： ADCY6
别名： AC6; ACVI; ADCY 6; ADCYB; Adenylate cyclase 6; Adenylate cyclase type 6; Adenylate cyclase type VI; ATP pyrophosphate lyase 6; Ca(2+) inhibitable adenylyl cyclase; DKFZp779F075; EC 4.6.1.1; KIAA0422;
分子量： 130kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ADCY6
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Sheep, hu, mo, rat, cow, hrs, pig, shp
细胞定位：细胞膜
腺苷酸环化酶6抗体产品介绍：background: The membrane-bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein-coupled receptors. Eight human AC isoforms (AC1 through AC4), encoded by separate genes, have been identified up to now. Most of the adenylate cyclase genes are comprised of 11-26 exons and distributed over a q6-430 kb. The majority of the adenylate cyclases previously described are expressed discretely in defined peripheral tissues, the type 4 adenylate cyclase (AC4) is apparently expressed in a variety of peripheral tissues and in the central nervous system, mainly in olfactory system. AC5 proteins are localized on photoreceptor cells and are also designated as GC1 and GC2. The AC5 protein resembles the other adenylyl cyclases in its predicted and proposed structure. AC5 resembles the type 6 (AC6) adenylyl cyclase in its amino acid sequence but becomes divergent at N and C-terminal ends. The AC5 and AC6 proteins are 腺苷酸环化酶6抗体co-localized in most of the visual organs (photoreceptor cells) and are associated with other protein complexes. Both AC5 and AC6 enzymes play an important role in synaptic plasticity by coordinating overlapping synaptic inputs from Gs and Gi coupled receptor stimulation. Function: Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity). Subunit: Part of a complex containing AKAP5, ADCY5, PDE4C and PKD2 (By similarity). Interacts with RAF1. Subcellular Location: Membrane; Multi-pass membrane protein. Cell projection, cilium (By similarity). Post-translational modifications: Phosphorylated by RAF1. Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains.腺苷酸环化酶6抗体 Database links: UniProtKB/Swiss-Prot: O43306.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
腺苷酸环化酶6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导 生长因子和** 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid