嗜酸性粒细胞过氧化物酶抗体
规格：1mg/1ml
英文名： EPX
别名： Eosinophil peroxidase; Eosinophil peroxidase heavy chain; EPER; EPO; EPP; EPX PEN; PERE; PERE_HUMAN.
分子量： 79kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Eosinoph
交叉反应：Human, Mouse, Rat,
细胞定位：
嗜酸性粒细胞过氧化物酶抗体产品介绍：background: EPX, eosinophil peroxidase, is an antimycobacterial protein that localizes to cytoplasmic granules of eosinophils and recruits bromide to generate a halogenating oxidant. EPX dependent generation of hypobromous acid causes damage to tissue during inflammatory conditions that include asthma, allergies,cancer and parasitic/helminthic infections. EPX is a major enzyme present in eosinophils and upon degranulation, becomes released into the airways of asthmatics. As a result of its cationic nature and its ability to catalyze the formation of highly toxic oxidants, EPX can induce lung injury in a JNK dependent manner. Function: Mediates tyrosine嗜酸性粒细胞过氧化物酶抗体 nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. Subunit: Tetramer of two light chains and two heavy chains. Subcellular Location: Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils. DISEASE: Defects in EPX are the cause of eosinophil peroxidase deficiency (EPD) [MIM:261500]. EPD is an autosomal recessive defect where anomalous eosinophils are characterized by nuclear hypersegmentation, hypogranulation, and negative peroxidase and phospholipid staining. Similarity: Belongs to the peroxidase family. XPO subfamily. Database links: 嗜酸性粒细胞过氧化物酶抗体UniProtKB/Swiss-Prot: P11678.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
嗜酸性粒细胞过氧化物酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid