羟类固醇脱氢酶17β-HSD抗体
规格：1mg/1ml
英文名： HSD17B1
别名： 11beta-HSD1; 17beta-HSD1; 17 beta HSD 1; 17 beta hydroxysteroid dehydrogenase type 1; 17β-hydroxysteroid dehydrogenasetype 1 EDH17B2; EDHB17; Estradiol 17 beta dehydrogenase 1; HSD17; Hydroxysteroid (
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HSD17B1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
羟类固醇脱氢酶17β-HSD抗体产品介绍：background: The principal human estrogen, 17 beta-estradiol, is a potent stimulator of certain endocrine-dependent forms of breast cancer. Because human estrogenic 17 beta-hydroxysteroid dehydrogenase (HSD17B1) catalyzes the last step in the biosynthesis of 17 beta-estradiol from the less potent estrogen, estrone, it is an attractive target for the design of inhibitors of estrogen production and tumor growth. It is concluded that the steroid-binding site of human placental HSD17B1 contains a histidine residue which proximates the upper A-ring region of the steroid as it undergoes the reversible binding step. Human estrogenic HSD17B1羟类固醇脱氢酶17β-HSD抗体 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies. Defects in the conversion of androstenedione to testosterone in the fetal testes by the enzyme HSD17B1 give rise to genetic males with female external genitalia. Subunit: Homodimer. Subcellular Location: Cytoplasm. Similarity: 羟类固醇脱氢酶17β-HSD抗体Belongs to the short-chain dehydrogenases/reductases (SDR) family. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Ⅰ型17β-羟类固醇脱氢酶又称Ⅰ型17HSD，催化雌酮与雌二醇之间的转化，为性**合成过程中*后步骤的催化酶。它催化性**Ｃ17位上的酮基和醇基之间的还原和氧化反应 ,使低生物活性的雌酮、雄烯二酮与高生物活性的雌二醇、睾酮之间相互转化。17βHSD的结构和功能的异常与一些** ,如肿瘤、假两性等的发生有密切关系.
羟类固醇脱氢酶17β-HSD抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 生长因子和** 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid