β4整合素结合蛋白抗体
规格：1mg/1ml
英文名： eIF6
别名： b(2)gcn; B(2)GCN homolog; B4 integrin interactor; Binding protein of beta-4 integrin; CAB; eIF-6; EIF3A; EIF6; Eukaryotic translation initiation factor 3A; Eukaryotic translation initiation factor 6;
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
免疫原：KLH conjugated synthetic peptide derived from human ITGB4BP
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
β4整合素结合蛋白抗体产品介绍：background: Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by Intergrin beta 4 binding protein binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding several different isoforms have been found for this gene. Function: Binds to the 60S ribosomal subunit and prevents its association with theβ4整合素结合蛋白抗体 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity. Subunit: Belongs to the eIF-6 family. Subcellular Location: Cytoplasm. Nucleus. nucleolus. Shuttles between cytoplasm and nucleus/nucleolus. Tissue Specificity: Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level). Post-translational modifications: Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export.β4整合素结合蛋白抗体 Similarity: Belongs to the eIF-6 family. Database links: Entrez Gene: 3692 Human Entrez Gene: 419140 Chicken Entrez Gene: 286811 Cow Entrez Gene: 16418 Mouse Entrez Gene: 305506 Rat Entrez Gene: 100302338 Sheep Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产β4整合素结合蛋白抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 免疫学 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid