甲基化多聚腺苷酸结合蛋白抗体
规格：1mg/1ml
英文名： PABP (Methyl Arg455/460)
别名： PABP (Methyl Arg455/Arg460); Methyl PABP (Arg455/Arg460); Methyl PABP (Arg455/460); PAB 1; PAB1; PABP 1; PABP1; PABP-1; PABPC 1; PABPC1; PABPC2; PABPL1v Poly A binding protein 1; Poly A binding protei
分子量： 75kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised metylpeptide derived from human P
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：细胞核 细胞浆
甲基化多聚腺苷酸结合蛋白抗体产品介绍：background: This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]. Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.甲基化多聚腺苷酸结合蛋白抗体 Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. Subunit: Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1,甲基化多聚腺苷酸结合蛋白抗体 PABPC1 and CSDE1. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Ubiquitous. Post-translational modifications: Phosphorylated by MAPKAPK2. Methylated by CARM1. Arg-493 is dimethylated, probably to asymmetric dimethylarginine. Similarity: Belongs to the polyadenylate-binding protein type-1 family. Contains 1 PABC domain. Contains 4 RRM (RNA recognition motif) domains. Database links: NCBI Reference Sequence: NP_002559.2 UniProtKB/Swiss-Prot: P11940.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
甲基化多聚腺苷酸结合蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid