Ras蛋白脑组织同源类似物RHEB蛋白抗体
规格：1mg/1ml
英文名： RHEB
别名： GTP-binding protein Rheb; MGC111559; Ras homolog enriched in brain 2; Ras homolog enriched in brain; RHEB 2; RHEB-2 RHEB2; RHEB_HUMAN.
分子量： 20kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RHEB
交叉反应：Human, Mouse, Rat, Chicken, Cow, Horse,
细胞定位：细胞浆 细胞膜
Ras蛋白脑组织同源类似物RHEB蛋白抗体产品介绍：background: Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies demon-strate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway. TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2. Function: Stimulates the phosphorylationRas蛋白脑组织同源类似物RHEB蛋白抗体 of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity. Subunit: Binds to mTORC1 in a guanyl nucleotide-independent manner. Interacts directly with MTOR, MLST8 and RPTOR. Interacts with TSC2. Subcellular Location: Cell membrane; Lipid-anchor; Cytoplasmic side. Tissue Specificity: Ubiquitous. Highest Ras蛋白脑组织同源类似物RHEB蛋白抗体levels observed in skeletal and cardiac muscle. Post-translational modifications: Farnesylation is important for efficiently activating mTORC1-mediated signaling. Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation (By similarity). Similarity: Belongs to the small GTPase superfamily. Rheb family. Gene ID: 6009 Database links: Entrez Gene: 6009 Human Omim: 601293 Human SwissProt: Q15382 Human Unigene: 283521 Human Unigene: 568850 Human Unigene: 647068 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Ras蛋白脑组织同源类似物RHEB蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid