细胞衰老相关蛋白ASF1A抗体
规格：1mg/1ml
英文名： ASF1A
别名： Anti silencing function 1A; ASF1 anti silencing function 1 homolog A; CCG1 interacting factor A; CG9383; CGI 98; CGI98 protein; CIA; dASF1; hAsf1; hAsf1a; hCIA; Histone chaperone ASF1A; HSPC146; ASF1A
分子量： 23kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ASF1A
交叉反应：Human, Mouse, Rat, Pig, Cow,
细胞定位：细胞核
细胞衰老相关蛋白ASF1A抗体产品介绍：background: ASF1a belongs to the H3/H4 family of histone chaperone proteins. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication, repair and silencing. Function: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.细胞衰老相关蛋白ASF1A抗体 Subunit: Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1. Interacts with CDAN1. Found in a cytosolic complex with CDAN1, ASF1B, IPO4 and histones H3.1 and H4. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitously expressed. Post-translational modifications: Phosphorylated by TLK1 and TLK2. Highly phosphorylated in S-phase and at lower levels in M-phase. TLK2-mediated 细胞衰老相关蛋白ASF1A抗体phosphorylation at Ser-192 prevents proteasome-dependent degradation. Similarity: Belongs to the ASF1 family. Database links: UniProtKB/Swiss-Prot: Q9Y294.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. ASF1a能够促进细胞衰老并且是与衰老有关的细胞周期停滞所必须的。HIRA/ASF1a介导的SAHF的形成过程直接促进细胞脱离细胞周期循环进入衰老阶段。研究人员还推测HIRA和ASF1a的改变可能使细胞无法脱离细胞周期并可能导致癌症的发生。
细胞衰老相关蛋白ASF1A抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 染色质和核信号 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid