脯氨酸羟化酶2抗体
规格：1mg/1ml
英文名： PHD2
别名： SM 20; Zinc finger MYND domain containing protein 6; C1ORF12; Chromosome 1 Open Reading Frame 12; ECYT 3; ECYT3; EGL 9 homolog of C. elegans 1; EGL nine (C.elegans) homolog 1; Egl nine homolog 1; Egl
分子量： 47kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PHD2
交叉反应：Human, Mouse, Pig, Cow, Rabbit,
细胞定位：细胞核 细胞浆
脯氨酸羟化酶2抗体产品介绍：background: PHD2 protein catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. In the presence of oxygen, PHD2 converts specific prolyl residues in HIF alpha to hydroxyproline, leading to HIF alpha proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF levels are stable. This results in increased angiogenesis as HIF1 alpha regulates the expression of many angiogenesis-related genes. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: According to PubMed:11056053, widely 脯氨酸羟化酶2抗体expressed with highest levels in skeletal muscle and heart, moderate levels in pancreas, brain (dopaminergic neurons of ***** and fetal substantia nigra) and kidney, and lower levels in lung and liver. According to PubMed:12351678 widely expressed with highest levels in brain, kidney and adrenal gland. Expressed in cardiac myocytes, aortic endothelial cells and coronary artery smooth muscle. According to 脯氨酸羟化酶2抗体PubMed:12788921; expressed in ***** and fetal heart, brain, liver, lung, skeletal muscle and kidney. Also expressed in placenta. Highest levels in ***** heart, brain, lung and liver and fetal brain, heart spleen and skeletal muscle. Similarity: Contains 1 Fe2OG dioxygenase domain. Contains 1 MYND-type zinc finger. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
脯氨酸羟化酶2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 细胞凋亡 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid