抑凋亡基因bag1抗体
规格：1mg/1ml
英文名： Bag1
别名： Bag 1; Bag-1; BAG family molecular chaperone regulator 1; BCL 2 Associated Athanogene 1; BCL 2 associated athanogene; BCL 2 binding athanogene 1; BCL2 associated athanogene 1; BCL2 associated athanoge
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Bag1/RAP
交叉反应：Human, Mouse, Rat, Dog, Horse,
细胞定位：细胞核 细胞浆 细胞膜
抑凋亡基因bag1抗体产品介绍：background: The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq]. Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. Function: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. Subunit: Contains 1 BAG domain. Contains 1 ubiquitin-like domain. Subcellular Location: Cytoplasm. Nucleus. Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock; Nucleus. Cytoplasm. Isoform 1 localizes predominantly to the nucleus and Cytoplasm. Nucleus. 抑凋亡基因bag1抗体Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria. Tissue Specificity: Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma 抑凋亡基因bag1抗体cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines. Database links: Entrez Gene: 573 Human Entrez Gene: 12017 Mouse Entrez Gene: 297994 Rat Omim: 601497 Human SwissProt: Q99933 Human SwissProt: Q60739 Mouse SwissProt: B0K019 Rat Unigene: 377484 Human Unigene: 688 Mouse Unigene: 16320 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Bag1蛋白是一种多功能蛋白，起到抑凋亡的作用，与Bcl 2、Raf 1等联合，一同调节一些生长因子及其受体酪氨酸激酶，协同热休克蛋白70发挥转录调节的分子作用。
抑凋亡基因bag1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 细胞凋亡 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid