半胱氨酸蛋白酶8相关蛋白2抗体
规格：1mg/1ml
英文名： FLASH
别名： CASP 8 associated protein 2; CASP8 associated protein 2; CASP8AP2; Caspase 8 associated protein 2; CED 4; CED4; FLASH homolog; FLASH homolog RIP 25; FLASH homolog RIP25; FLICE associated huge; FLICE a
分子量： 218kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FLASH/CA
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：细胞核 细胞浆
半胱氨酸蛋白酶8相关蛋白2抗体产品介绍：background: FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8. There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity. Studies of FLASH protein suggested that this protein may be a component of the death inducing signaling complex that includes Fas receptor, Fas binding adapter FADD, and caspase 8, and plays a regulatory role in Fas mediated apoptosis. Function: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of 半胱氨酸蛋白酶8相关蛋白2抗体GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. Subunit: Self-associates. Component of the death-inducing signaling 半胱氨酸蛋白酶8相关蛋白2抗体complex (DISC) with CASP8, FADD and FAS. Interacts with NCOA2, NCOA3, SRRT/ARS2 and TRAF2. Interacts with NPAT. Subcellular Location: Cytoplasm. Nucleus. Note=Localizes to discrete nuclear foci. Database links: Entrez Gene: 9994 Human Entrez Gene: 26885 Mouse Omim: 606880 Human SwissProt: Q9UKL3 Human SwissProt: Q9WUF3 Mouse Unigene: 558218 Human Unigene: 22279 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CASP8AP2是一种与ced4具有同源结构域的蛋白,能诱导肿瘤细胞的凋亡。
半胱氨酸蛋白酶8相关蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid