丝束蛋白T Plastin抗体
规格：1mg/1ml
英文名： PLASTIN3
别名： Plastin 3 (T isoform); PLS3; PLS 3; PLS-3; Plastin 3; Plastin3; Plastin-3; T fimbrin.
分子量： 69kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PLASTIN3
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
丝束蛋白T Plastin抗体产品介绍：background: T Plastin is a representative of an important family of actin-cross-linking and -bundling proteins that organize most of the actin networks in cells. T Plastin is associated with the actin core bundle of microvilli, stereocilia and microspikes in epithelial cells and was proposed to participate in the assembly of these structures. In mesenchymal cells, T plastin localizes to focal adhesions and the leading edge, a broad lamellar membrane extension harboring a dynamic branched actin network. Recent studies have shown that T plastin has the potential to be a Sezary cell-specific marker valuable for diagnostic and treatment of Sezary syndrome.丝束蛋白T Plastin抗体 Function: Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. Subunit: Monomer. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in a variety of organs, including muscle, brain, uterus and esophagus. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR Similarity: Contains 2 actin-binding domains. Contains 4 CH (calponin-homology) domains. Contains 2 EF-hand domains. Database links: Entrez Gene: 5358 Human Entrez Gene: 102866 Mouse Entrez Gene: 81748 Rat Omim: 丝束蛋白T Plastin抗体300131 Human SwissProt: P13797 Human SwissProt: Q99K51 Mouse SwissProt: Q63598 Rat Unigene: 496622 Human Unigene: 28777 Mouse Unigene: 32103 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 丝束(纤毛素)是肌动蛋白结合蛋白家族的成员,存在于细胞支架的重组中. 丝束3是来源于纤毛素蛋白家族的T**细胞特异肌动蛋白成束蛋白。近年来T Plastin在用于sezary cell综合征的研究方面较多。
丝束蛋白T Plastin抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid