神经丛蛋白A2抗体
规格：1mg/1ml
英文名： Plexin A2
别名： PlexinA2; PLXA2; PLXNA2; Semaphorin receptor OCT.
分子量： 205kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Plexin A
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
神经丛蛋白A2抗体产品介绍：background: Plexin A2 is a coreceptor for SEMA3A and is necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. This coreceptor plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin in which the plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Function: Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. 神经丛蛋白A2抗体Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). Subunit: Homodimer. The PLXNA2 homodimer interacts with a SEMA6A homodimer, 神经丛蛋白A2抗体giving rise to a heterotetramer. Interacts directly with NRP1 and NRP2 (By similarity). Interacts with RND1. Subcellular Location: Cell membrane; Single-pass type I membrane protein (By similarity). Tissue Specificity: Detected in fetal brain. Similarity: Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 1 Sema domain. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Plexin A2蛋白是SEMA3A的辅助受体，Plexin A2蛋白在神经细胞轴突导向, 生长和细胞迁移中发挥作用。
神经丛蛋白A2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学 细胞膜受体 细胞表面分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid