踝蛋白抗体
规格：1mg/1ml
英文名： Talin
别名： TLN 1; ILWEQ; Talin 1; Talin; TLN; TLN1.
分子量： 280kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Talin
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆 细胞膜
踝蛋白抗体产品介绍：background: Talin, a multifunctional constituent of cell-substratum attachment sites, is a high molecular weight protein (225-270 kDa) found in variety of tissues and cell types. It is localized at a subset of adherens junctions, specialized cell-cell and cell-matrix associations that are characterized by the presence of filamentous actin at the cytoplasmic face of the junctional complex. In cultured cells, talin is absent from cell-cell junctions and found predominantly at adhesion plaques and in fibrillar streaks underlying cell surface fibronectin. Talin interacts with at least two other proteins that are localized at adhesion plaques, vinculin and integrin. Talin and vinculin have been shown to interact with each other and both have been proposed to be involved in generating the transmembrane connection, between the extracellular踝蛋白抗体 matrix and the cytoskeleton, that occurs at adhesion plaques. At physiological ionic strength, talin is an elongate, flexible, monomeric protein with the ability to self-associate into dimers at higher protein concentrations. Function: Probably involved in connections of major cytoskeletal structures Talin to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. Subunit: Binds with high affinity to VCL and with low affinity to integrins. Interacts with PTK2/FAK1 (By similarity). Interacts with PIP5K1C and NRAP. Interacts with LAYN. Interacts with SYNM. Subcellular Location: Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Colocalizes with LAYN at the membrane ruffles. Similarity: FERM domain. Contains 1 I/LWEQ domain. 踝蛋白抗体Gene ID: 7094 Database links: Entrez Gene: 395194 Chicken Entrez Gene: 7094 Human Entrez Gene: 21894 Mouse Entrez Gene: 313494 Rat Omim: 186745 Human SwissProt: P54939 Chicken SwissProt: Q9Y490 Human SwissProt: P26039 Mouse Unigene: 471014 Human Unigene: 208601 Mouse Unigene: 7715 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. TALIN-踝蛋白。是重要的细胞骨架肌动蛋白结合蛋白，由两个270kDa的亚单位组成的反向 平行的同源二聚体，与整合蛋白B尾部的结合诱导了整合蛋白胞外结构域构象的改变,起到了对整合蛋白的激活。
踝蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 转录调节因子 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid