金属应答元件结合转录因子-1抗体
规格：1mg/1ml
英文名： MTF-1
别名： Metal regulatory transcription factor 1; Metal response element binding transcription factor 1; MRE binding transcription factor; Transcription factor MTF1; MTF1_HUMAN.
分子量： 81kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MTF-1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核
金属应答元件结合转录因子-1抗体产品介绍：background: The zinc finger transcription factor MTF-1 (metal-responsive transcription factor-1) is conserved from insects to vertebrates. The major role of MTF-1 in both organisms is to control the transcription of genes involved in the homeostasis and detoxification of heavy metal ions such as Cu2+, Zn2+ and Cd2+. In mammals, MTF-1 serves at least two additional roles. First, targeted disruption of the MTF-1 gene results in death at embryonic day 14 due to liver degeneration, revealing a 金属应答元件结合转录因子-1抗体stage-specific developmental role. Second, under hypoxic-anoxic stress, MTF-1 helps to activate the transcription of the gene placental growth factor (PIGF), an angiogenic protein. Function: Activates the metallothionein I promoter金属应答元件结合转录因子-1抗体. Binds to the metal responsive element (MRE). Subcellular Location: Nucleus. Similarity: Contains 6 C2H2-type zinc fingers. Gene ID: 4520 Database links: Entrez Gene: 4520 Human Omim: 600172 Human SwissProt: Q14872 Human Unigene: 471991 Human Unigene: 591505 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 锌感应蛋白金属反应转录因子-1
金属应答元件结合转录因子-1抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 染色质和核信号 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid