肌细胞生成素抗体
规格：1mg/1ml
英文名： Myogenin
别名： MYOG; bHLHc3; cb553; MYF 4; MYF4; Myf-4; MYOG; Myogenic factor 4; Myogenic factor 4 myogenin; MYOGENIN; Myogenin myogenin factor 4; OTTHUMP00000039094; Class C basic helix-loop-helix protein 3; MYOG_H
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MYOG/Myo
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
肌细胞生成素抗体产品介绍：background: Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008] Function: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in ***** denervated muscles. Induces fibroblasts to differentiate into myoblasts. Subunit: Homodimer and heterodimer with E12; heterodimerization enhances MYOG DNA-binding and transcriptional activities. Interacts with SMARCA4/BRG1/BAF190A. Interacts 肌细胞生成素抗体(via C-terminus region) with SSRP1 and SUPT16H; the interaction is indicative of an interaction with the FACT complex. Subcellular Location: Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos. Post-translational modifications: Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles. Similarity: Contains 1 bHLH (basic helix-loop-helix) domain. Gene ID: 4656 Database links: Entrez Gene: 4656 Human Entrez Gene: 17928 Mouse Entrez Gene: 497618 Pig Entrez Gene: 29148 Rat Omim: 159980 Human SwissProt: P15173 Human SwissProt: 肌细胞生成素抗体P12979 Mouse SwissProt: P49812 Pig SwissProt: P20428 Rat Unigene: 2830 Human Unigene: 16528 Mouse Unigene: 9465 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. MYOG是肌肉中运载氧的蛋白质，由153个氨基酸残基组成，一种小分子蛋白质，含有血红素，和血红蛋白同源，与氧的结合能力介于血红蛋白和细胞色素氧化酶之间，可帮助肌细胞将氧转运到线粒体。 肌细胞生成素在成肌分化过程中起着决定性的作用。在人体骨骼肌的胚胎发育过程中 ,肌细胞生成素伴随成肌过程而呈高水平表达。MYOG主要由肾脏代谢并排泄，当心肌或横纹肌有损伤时，肌红蛋白便释放入血中，血清中的肌红蛋白即可明显升高。
肌细胞生成素抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 激酶和磷酸酶 结合蛋白 细胞表面分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid