磷酸化酪氨酸羟化酶抗体
规格：1mg/1ml
英文名： Phospho-Tyrosine Hydroxylase (Ser40)
别名： Tyrosine Hydroxylase (Phospho-Ser40); Tyrosine Hydroxylase; DYT14; DYT5b; ple; Protein Pale; TH; The; TYH; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; TY3H_HUMAN.
分子量： 58kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from rat T
交叉反应：Human,
细胞定位：
磷酸化酪氨酸羟化酶抗体产品介绍：background: Neuronal Marker Tyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease. Function: Plays an important role in the physiology of adrenergic neurons. Tissue Specificity: Mainly expressed in the brain and adrenal glands. DISEASE: Segawa syndrome autosomal recessive (ARSEGS) [MIM:605407]: A form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable 磷酸化酪氨酸羟化酶抗体response to L-DOPA. Note=The disease is caused by mutations affecting the gene represented in this entry. Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls. Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. Gene ID: 25085 Database links: Entrez Gene: 7054 Human Entrez Gene: 21823 Mouse Entrez Gene: 25085 Rat Omim: 191290 Human SwissProt:磷酸化酪氨酸羟化酶抗体 P07101 Human SwissProt: P24529 Mouse SwissProt: P04177 Rat Unigene: 435609 Human Unigene: 1292 Mouse Unigene: 11082 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神经细胞标志物 酪氨酸羟化酶（TH）是儿茶酚胺类神经递质即多巴胺、去甲肾上腺素、肾上腺素生物合成过程所需的限速酶，它以四氢生物喋呤啶(BH4)为辅酶，催化酪氨酸的羟化而生成多巴(DOPA)。 已知在患帕金森病(Parkinson disease,PD)时，脑内多巴胺(dopamine,DA)的减少与此酶活性低下有关。因此对PD模型动物来说，若将TH基因植入脑内，便可以提高脑内DA水平而达到基因**目的。
磷酸化酪氨酸羟化酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学 信号转导 转录调节因子 激酶和磷酸酶 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid