磷酸化S6核糖体蛋白(Ser240/244)抗体
规格：1mg/1ml
英文名： Phospho-RPS6 (Ser240 + Ser244)
别名： RPS6 (phospho S240 + S244); p-RPS6 (phospho S240 + S244); Air8; DS6; Hemocytes enlarged; Hen; L(1)AIR8; Lethal (1) haemocytes enlarged; Lethal aberrant immune response 8; Lethal(1)abberant immune resp
分子量： 29kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat,
细胞定位：
磷酸化S6核糖体蛋白(Ser240/244)抗体产品介绍：background: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of 磷酸化S6核糖体蛋白(Ser240/244)抗体this gene dispersed through the genome. [provided by RefSeq, Jul 2008] Function: May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Post-translational modifications: Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphrylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex. Similarity: Belongs to the ribosomal protein S6e family. Gene ID: 6194磷酸化S6核糖体蛋白(Ser240/244)抗体 Database links: Entrez Gene: 6194 Human Entrez Gene: 20104 Mouse Entrez Gene: 667739 Mouse Entrez Gene: 29304 Rat Omim: 180460 Human SwissProt: P62753 Human SwissProt: P62754 Mouse SwissProt: P62755 Rat Unigene: 408073 Human Unigene: 379007 Mouse Unigene: 425090 Mouse Unigene: 34341 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化S6核糖体蛋白(Ser240/244)抗体产品应用：WB=1:100-1000 ELISA=1:100-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 染色质和核信号 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid