磷酸化核糖体蛋白S6激酶家族RSK3抗体
规格：1mg/1ml
英文名： Phospho-RSK3 (Thr353 + Thr356)
别名： RSK3 (Phospho T353 + T356); Phospho-RSK3 (Thr353 + Thr356); 90 kDa ribosomal protein S6 kinase 2; HU 2; KS6A2_HUMAN; MAP kinase activated protein kinase 1c; MAP kinase-activated protein kinase 1c; MAP
分子量： 83kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep, Guinea Pig,
细胞定位：
磷酸化核糖体蛋白S6激酶家族RSK3抗体产品介绍：background: RSK3(Ribosomal S6 kinase 3)is a member of a family of 90-kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine/threonine protein kinases that are activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2. Rsk3 is a distinct isoform of p90Rsk that translocates to the cell nucleus, phosphorylates potential nuclear targets and may have a unique upstream activator. Several sites, such as Ser380, Thr359, Ser363 and Thr573, are important for its activation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c Fos and CREB. Function: Serine/threonine-protein kinase that acts downstream ofERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenicand stress-induced activation of transcription factors, regulatestranslation, and mediates cellular proliferation, survival, anddifferentiation. May function as tumor suppressor in epithelialovarian cancer cells. Subunit: Forms a complex with either MAPK1/ERK2 磷酸化核糖体蛋白S6激酶家族RSK3抗体or MAPK3/ERK1 inquiescent cells. Transiently dissociates following mitogenicstimulation. Subcellular Location: Nucleus. Cytoplasm. Tissue Specificity: Widely expressed with higher expression inlung, skeletal muscle, brain, uterus, ovary, thyroid and prostate. Post-translational modifications: Activated by phosphorylation at Ser-218 by PDPK1.Autophosphorylated on Ser-377, as part of the activation process.May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 andMAPK3/ERK1. N-terminal myristoylation results in an activated kinase inthe absence 磷酸化核糖体蛋白S6激酶家族RSK3抗体of added growth factors. Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thrprotein kinase family. S6 kinase subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 2 protein kinase domains. Gene ID: 6196 Database links: Entrez Gene: 6196 Human Entrez Gene: 20112 Mouse Entrez Gene: 117269 Rat Omim: 601685 Human SwissProt: Q15349 Human SwissProt: Q9WUT3 Mouse Unigene: 655277 Human Unigene: 268383 Mouse Unigene: 2356 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化核糖体蛋白S6激酶家族RSK3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid