磷酸化磷酯酶Cγ2抗体
规格：1mg/1ml
英文名： Phospho-PLCG 2 (Tyr1217)
别名： PLCG 2 (phospho Y1217); p-PLCG 2 (phospho Y1217); PLCG2(phospho Y1217); Phospho-PLC γ2(Tyr1217); Phospho-PLC gamma 2/PLCG2(Tyr1217); PLC 2; PLC gamma 2; PLC IV; PLCG2; 1 phosphatidylinositol 4 5 bisph
分子量： 139kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：细胞浆
磷酸化磷酯酶Cγ2抗体产品介绍：background: Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide specific phospholipase C enzymes, C beta is regulated by heterotrimeric G protein coupled receptors, while the closely related C gamma 1 and C gamma 2 enzymes are controlled by receptor tyrosine kinases. The C gamma 1 and C gamma 2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3. Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by磷酸化磷酯酶Cγ2抗体 activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. Subunit: Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity). Post-translational modifications: Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity. Similarity: Contains 1 C2 domain. Contains 1 PH domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC 磷酸化磷酯酶Cγ2抗体Y-box domain. Contains 2 SH2 domains. Contains 1 SH3 domain. Gene ID: 5336 Database links: Entrez Gene: 5336 Human Entrez Gene: 234779 Mouse Entrez Gene: 29337 Rat Omim: 600220 Human SwissProt: P16885 Human SwissProt: Q8CIH5 Mouse SwissProt: P24135 Rat Unigene: 413111 Human Unigene: 192699 Mouse Unigene: 9751 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化磷酯酶Cγ2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导 转录调节因子 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid