磷酸化PDZ连接激酶/T-LAK细胞源蛋白激酶抗体
规格：1mg/1ml
英文名： Phospho-PBK (Thr9)
别名： PBK (phospho T9); PBK (phospho Thr9); Cancer/testis antigen 84; CT84; FLJ14385; Lymphokine activated killer T cell originated protein kinase; MAPKK like protein kinase; PDZ-binding-kinase/T-LAK cell-o
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat,
细胞定位：
磷酸化PDZ连接激酶/T-LAK细胞源蛋白激酶抗体产品介绍：background: This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Function: Phosphorylates MAP kinase p38. Seems to be active only in mitosis.磷酸化PDZ连接激酶/T-LAK细胞源蛋白激酶抗体 May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Subunit: Interacts with DLG1 and TP53. Tissue Specificity: Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. Post-translational modifications: Phosphorylated; in a cell-cycle dependent manner at mitosis. Similarity: Belongs to the protein kinase superfamily.磷酸化PDZ连接激酶/T-LAK细胞源蛋白激酶抗体 Ser/Thr protein kinase family. MAP kinase kinase subfamily. Contains 1 protein kinase domain. Gene ID: 55872 Database links: Entrez Gene: 55872 Human Omim: 611210 Human SwissProt: Q96KB5 Human Unigene: 104741 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PBK/TOPK是一种新近发现的丝-苏氨酸激酶,属于MAPKK分子家族成员，具有参与调控恶性肿瘤细胞的增殖和周期变化, 促进肿瘤细胞转化, 并且通过MAPKK信号通路参与调控细胞DNA损伤修复.
磷酸化PDZ连接激酶/T-LAK细胞源蛋白激酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid