磷酸化蛋白酶活化受体4抗体
规格：1mg/1ml
英文名： Phospho-PAR4 (Thr163)
别名： PAR 4; Par4 induced by effectors of apoptosis; PAWR; PRKC Apoptosis WT1 Regulator; PRKC apoptosis WT1 regulator protein; Prostate apoptosis response 4 protein; Prostate apoptosis response protein 4; P
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat,
细胞定位：
磷酸化蛋白酶活化受体4抗体产品介绍：background: PAR4 is a member of a unique family of GPCRs, the proteinase-activated receptors (PARs), that are activated by proteolytic cleavage of the N-terminal domain of the receptor to reveal a tethered ligand. The PAR family consists of 4 receptors; PAR1 and PAR3 are activated by thrombin, and PAR2 and PAR4 are activated by several serine proteases (Macfarlane et al., 2001). PAR4 is expressed along with PAR1 on human platelets, and each plays an important role in thrombin-induced platelet aggregation (Holinstat et al., 2006). However, platelets from mice express PAR4 but not PAR1, and platelets from mice lacking PAR4 fail to aggregate in response to thrombin (Sambrano et al., 2001). Mice lacking PAR4 are protected from mesenteric arteriole thrombosis, indicating that PAR4 is a potential target for treatment of thrombosis in humans. Function: Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed,磷酸化蛋白酶活化受体4抗体 with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets. Post-translational modifications: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 5074 Database links: Entrez Gene: 5074 Human Entrez Gene: 114774 Mouse Entrez Gene: 64513 Rat Omim: 601936 Human SwissProt: Q96IZ0 Human SwissProt: Q925B0 Mouse SwissProt: Q62627 Rat Unigene: 643130 Human Unigene: 391419 Mouse Unigene: 9127 Rat Important Note: This product as supplied is intended for research use only,磷酸化蛋白酶活化受体4抗体 not for use in human, therapeutic or diagnostic applications. 蛋白酶活化受体-4(前列腺细胞凋亡反应蛋白4)是蛋白酶活化受体PARs (protease-activated receptors , PARs)的成员之一，PAR4在激活、灭活、**、复敏、及其与信号转导途径的关系,尤其是与**的关系正倍受关注。 PAR4具有广泛的生物学效应,*终影响细胞的形态的改变、分泌蛋白和整合蛋白的活化、代谢反应、转录过程和细胞运动，由此参与细胞的信号转导作用。
磷酸化蛋白酶活化受体4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导 细胞凋亡 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid