磷酸化膜相关蛋白Numb抗体
规格：1mg/1ml
英文名： Phospho-Numb (Ser276)
别名： Numb (phospho S276); Numb (phospho Ser276); p-Numb (Ser276); c14_5527; C14orf41; FLJ31314; h Numb; h-Numb; Numb; Numb homolog (Drosophila); Numb homolog; Numb protein homolog; NUMB_HUMAN; Protein numb
分子量： 70kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
磷酸化膜相关蛋白Numb抗体产品介绍：background: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Function: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. Subunit: Interacts with CDH1 and TFAP2B (By similarity). Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with 磷酸化膜相关蛋白Numb抗体RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis. Subcellular Location: Membrane; Peripheral membrane protein. Post-translational modifications: Phosphorylated on Ser-276 and Ser-295 by CaMK1. Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation. Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. Similarity: Contains 1 PID domain. Gene ID: 8650 Database links: Entrez Gene: 8650 Human Entrez Gene: 18222 Mouse Entrez Gene: 磷酸化膜相关蛋白Numb抗体29419 Rat Omim: 603728 Human SwissProt: P49757 Human SwissProt: Q9QZS3 Mouse SwissProt: Q2LC84 Rat Unigene: 654609 Human Unigene: 714879 Human Unigene: 4390 Mouse Unigene: 102078 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 膜相关蛋白Numb是细胞命运决定因子：在细胞有丝分裂期，Numb选择性地分布于细胞的一侧,在胞质分裂后则被分配于一个子细胞，Numb通过抑制跨膜受体Notch而发挥作用, Numb信号途径在前体细胞的神经元调控方面起着重要作用.
磷酸化膜相关蛋白Numb抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 细胞膜受体 细胞表面分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit