磷酸化丙氨酸蛋白激酶C底物Marcks抗体
规格：1mg/1ml
英文名： Phospho-MARCKS (Ser152 + Ser156)
别名： MARCKS (phospho S152 + S156); p-MARCKS (phospho S152 + S156); MARCKS (phospho S159 + S163); 80 kDa protein; 80K L; 80K L protein; 80K-L protein; 80KL; 81 kDa protein, light chain; light chain; MACS; M
分子量： 30kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from rat M
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit,
细胞定位：细胞浆 细胞膜
磷酸化丙氨酸蛋白激酶C底物Marcks抗体产品介绍：background: The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008] Function: MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous 磷酸化丙氨酸蛋白激酶C底物Marcks抗体(F) actin cross-linking protein. Subcellular Location: Cytoplasm, cytoskeleton (Probable). Membrane; Lipid-anchor. Tissue Specificity: Highest levels found in spleen and brain. Intermediate levels seen in thymus, ovary, lung and heart. Very low levels seen in kidney, skeletal muscle and liver. Post-translational modifications: Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity. Similarity: Belongs to the MARCKS family. Gene ID: 25603 Database links: Entrez Gene: 4082 Human Entrez Gene: 磷酸化丙氨酸蛋白激酶C底物Marcks抗体17118 Mouse Entrez Gene: 25603 Rat Omim: 177061 Human SwissProt: P29966 Human SwissProt: P26645 Mouse SwissProt: P30009 Rat Unigene: 519909 Human Unigene: 712721 Human Unigene: 30059 Mouse Unigene: 9560 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. MARCKS是一种分子量为32kDa的膜内蛋白,在组织中广泛表达,但主要高表达在脑内的轴突、小直径的树突和树突棘.
磷酸化丙氨酸蛋白激酶C底物Marcks抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 **学 信号转导 激酶和磷酸酶 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid