磷酸化多巴胺/cAMP调节神经磷蛋白抗体
规格：1mg/1ml
英文名： Phospho-DARPP32 (Thr34)
别名： DARPP32 (phospho T34); p-DARPP32 (phospho T34); Ppp1r1b(phospho T34); DARPP 32; Dopamine and cAMP regulated neuronal phosphoprotein; Dopamine and cAMP regulated phosphoprotein DARPP 32; Dopamine and c
分子量： 32kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig,
细胞定位：
磷酸化多巴胺/cAMP调节神经磷蛋白抗体产品介绍：background: This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. Function: Inhibitor of protein-phosphatase 1. Subcellular Location: Cytoplasm. Post-translational modifications: Phosphorylation of Thr-34 is required for activity. Similarity: Belongs to the protein phosphatase i磷酸化多巴胺/cAMP调节神经磷蛋白抗体nhibitor 1 family. Gene ID: 84152 Database links: Entrez Gene: 84152 Human Entrez Gene: 19049 Mouse Entrez Gene: 360616 Rat Omim: 604399 Human SwissProt: Q9UD71 Human SwissProt: Q60829 Mouse SwissProt: Q6J4I0 Rat Unigene: 286192 Human Unigene: 45372 Mouse Unigene: 70366 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. DARPP-32通过自身不同位点的磷酸化对蛋白质磷酸化和去磷酸化过程发挥着双向调控的作用.磷酸化多巴胺/cAMP调节神经磷蛋白抗体DARRP-32在脑内存在于接受多巴胺能投射的神经元中,其磷酸化过程受多种神经递质的调控,在信号转导途径中处于中心位置,整合多种胞内信号转导,调节神经元的电学和化学性质以及动物的生理行为反应,参与多种生理功能和病理过程,包括**成瘾、抑郁症、精神分裂症等.此外,DARPP-32在非神经系统的功能也逐渐被人们所认识. 多巴胺和cAMP调节的磷蛋白(dopamine and adenosine 3'5'-monophosphate-regulated phospho-protein,Mr 32 kD,DARPP-32)是一个具有双重功能的独特蛋白,它既是磷酸酶(如PP-1)的抑制剂,也是蛋白激酶(如PKA)的抑制剂。
磷酸化多巴胺/cAMP调节神经磷蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid