磷酸化Disabled 1抗体
规格：1mg/1ml
英文名： Phospho-Dab1 (Tyr220)
别名： Dab 1; Disabled homolog 1; Disabled homolog 1 Drosophila; Scm; Scr; Scrambler; Yot; Yotari; Dab, reelin signal transducer, homolog 1 (Drosophila); Dab1; DAB1_HUMAN.
分子量： 65kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit,
细胞定位：
磷酸化Disabled 1抗体产品介绍：background: The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008] Function: Adapter molecule functioning in neural development. May regulate SIAH1 activity. Subunit: Associates with the SH2 domains of SRC, FYN and ABL. Interacts with磷酸化Disabled 1抗体 DAB2IP and SIAH1. Interacts with LRP1. Post-translational modifications: Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling. Similarity:磷酸化Disabled 1抗体 Contains 1 PID domain. Gene ID: 1600 Database links: Entrez Gene: 374083 Chicken Entrez Gene: 1600 Human Entrez Gene: 13131 Mouse Entrez Gene: 266729 Rat Entrez Gene: 692351 Zebrafish Omim: 603448 Human SwissProt: O75553 Human SwissProt: P97318 Mouse SwissProt: Q8CJH2 Rat Unigene: 477370 Human Unigene: 289682 Mouse Unigene: 206534 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化Disabled 1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid