转录因子HES-1抗体
规格：1mg/1ml
英文名： HES1
别名： bHLHb39; C-HAIRY1; c-hairy1A; Class B basic helix-loop-helix protein 39; FLJ20408; Hairy and enhancer of split 1 (Drosophila); Hairy and enhancer of split 1; Hairy Enhancer of Split 1; Hairy homolog (
分子量： 30kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HES1
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核
转录因子HES-1抗体产品介绍：background: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. Function: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. Subunit: Transcription repression requires formation of a complex 转录因子HES-1抗体with a corepressor protein of the Groucho/TLE family. Interacts (via WPRW motif) with TLE1, and more weakly with TLE2. Interacts with HES6 (By similarity). Interacts with SIRT1. Interacts with an FA complex, composed of FANCA, FANCF, FANCG and FANCL, but not of FANCC, nor FANCE. Subcellular Location: Nucleus. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 Orange domain. Gene ID: 3280 Database links: Entrez Gene: 395128 Chicken Entrez Gene: 539547 Cow Entrez Gene: 3280 Human Entrez Gene: 15205 Mouse Entrez Gene: 转录因子HES-1抗体100499567 Pig Entrez Gene: 29577 Rat Omim: 139605 Human SwissProt: O57337 Chicken SwissProt: Q3ZBG4 Cow SwissProt: Q14469 Human SwissProt: P35428 Mouse SwissProt: Q04666 Rat Unigene: 250666 Human Unigene: 390859 Mouse Unigene: 19727 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
转录因子HES-1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 染色质和核信号 神经生物学 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid