肿瘤坏死因子受体1抗体
规格：1mg/1ml
英文名： TNFR1
别名： TNFRSF1a; CD120a; CD120a antigen; MGC19588; p55; p55 R; p55R; p60; TBP1; TBPI; TNF R; TNF R I; TNF R1; TNF R55; TNF-R1; Soluble TNF Receptor I; Soluble TNF p55 Receptor; TNF-RI; TNFR 1; TNFR I; TNFR-I
分子量： 50kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TNFR1/TN
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
肿瘤坏死因子受体1抗体细胞定位：细胞膜 分泌型蛋白
产品介绍：background: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Function: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Subcellular Location: Cell membrane. Secreted. Post-translational modifications: The soluble form is produced from the membrane form by肿瘤坏死因子受体1抗体 proteolytic processing. DISEASE: Defects in TNFRSF1A are the cause of familial hibernian fever (FHF) [MIM:142680]; also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS). FHF is a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases. Similarity: Contains 1 death domain. Contains 4 TNFR-Cys repeats. Database links: Entrez Gene: 282527 Cow Entrez Gene: 403634 Dog Entrez Gene:肿瘤坏死因子受体1抗体 7132 Human Entrez Gene: 21937 Mouse Entrez Gene: 397020 Pig Entrez Gene: 25625 Rat Entrez Gene: 100135698 Sheep Entrez Gene: 100137626 Xenopus laevis Omim: 191190 Human SwissProt: O19131 Cow SwissProt: P19438 Human SwissProt: P25118 Mouse SwissProt: P50555 Pig SwissProt: P22934 Rat Unigene: 279594 Human Unigene: 713833 Human Unigene: 1258 Mouse Unigene: 11119 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肿瘤坏死因子受体1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 信号转导 干细胞 细胞凋亡 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid